CCKAR [The Human Chemical-Genetic Interaction Map Project]

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======= CCKAR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCKAR
  * **<color #00a2e8>Official Name</color>**: cholecystokinin A receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=886|886]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P32238|P32238]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCKAR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCKAR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118444|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CholecysA-Rec N|
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cholecystokinin signaling pathway|
|cholecystokinin receptor activity|
|peptide hormone binding|
|feeding behavior|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|neuron migration|
|regulation of hormone secretion|
|axonogenesis|
|forebrain development|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|regulation of hormone levels|
|cell morphogenesis involved in differentiation|
|behavior|
|cellular response to hormone stimulus|
|neuron projection development|
|cell morphogenesis|
|brain development|
|regulation of secretion by cell|
|head development|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|response to hormone|
|cell migration|
|central nervous system development|
|neuron differentiation|
|cell motility|
|localization of cell|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.85|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.9|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.97|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14015
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCKAR Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>