CCKAR

Entrez Summary: This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Ammonium tetrathiomolybdate 10μM R08 exp448	1.85
Quercetin 20μM R08 exp517	1.9
MS023 2μM R03 exp134	1.97
Beta-Estradiol 0.55μM R07 exp425	2.04

cholecystokinin signaling pathway
cholecystokinin receptor activity
peptide hormone binding
feeding behavior
phospholipase C-activating G protein-coupled receptor signaling pathway
neuron migration
regulation of hormone secretion
axonogenesis
forebrain development
axon development
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
regulation of hormone levels
cell morphogenesis involved in differentiation
behavior
cellular response to hormone stimulus
neuron projection development
cell morphogenesis
brain development
regulation of secretion by cell
head development
regulation of secretion
neuron development
cellular component morphogenesis
response to hormone
cell migration
central nervous system development
neuron differentiation
cell motility
localization of cell
plasma membrane bounded cell projection organization
cell projection organization
cellular response to endogenous stimulus
locomotion
G protein-coupled receptor signaling pathway
integral component of plasma membrane
response to endogenous stimulus