CD109 [The Human Chemical-Genetic Interaction Map Project]

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======= CD109 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD109
  * **<color #00a2e8>Official Name</color>**: CD109 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=135228|135228]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6YHK3|Q6YHK3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD109&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD109|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608859|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|A2M recep|
|A2M comp|
|A2M N 2|
|A2M N|
|Thiol-ester cl|
|A2M|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|osteoclast fusion|
|multinuclear osteoclast differentiation|
|negative regulation of keratinocyte proliferation|
|platelet alpha granule membrane|
|transforming growth factor beta binding|
|regulation of keratinocyte proliferation|
|syncytium formation by plasma membrane fusion|
|cell-cell fusion|
|syncytium formation|
|regulation of keratinocyte differentiation|
|osteoclast differentiation|
|regulation of epidermal cell differentiation|
|negative regulation of wound healing|
|hair follicle development|
|skin epidermis development|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|molting cycle process|
|hair cycle process|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of response to wounding|
|regulation of epidermis development|
|molting cycle|
|hair cycle|
|serine-type endopeptidase inhibitor activity|
|anchored component of membrane|
|myeloid leukocyte differentiation|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of epithelial cell proliferation|
|platelet degranulation|
|regulation of wound healing|
|regulation of epithelial cell differentiation|
|negative regulation of cellular response to growth factor stimulus|
|regulation of response to wounding|
|myeloid cell differentiation|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|regulation of cellular response to growth factor stimulus|
|leukocyte differentiation|
|regulation of epithelial cell proliferation|
|negative regulation of proteolysis|
|negative regulation of response to external stimulus|
|skin development|
|negative regulation of protein phosphorylation|
|epidermis development|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of phosphorylation|
|negative regulation of hydrolase activity|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|hematopoietic or lymphoid organ development|
|cell surface|
|immune system development|
|negative regulation of cell population proliferation|
|regulated exocytosis|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|exocytosis|
|anatomical structure formation involved in morphogenesis|
|secretion by cell|
|negative regulation of cellular protein metabolic process|
|export from cell|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|epithelium development|
|secretion|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10074
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD109 Expression in NALM6 Cells: 5.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>