CD109

Gene Information

Official Symbol: CD109
Official Name: CD109 molecule
Aliases and Previous Symbols: N/A
Entrez ID: 135228
UniProt: Q6YHK3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10074
Expression level (log2 read counts): 5.59

Expression Distribution

A2M recep
A2M comp
A2M N 2
A2M N
Thiol-ester cl
A2M

osteoclast fusion
multinuclear osteoclast differentiation
negative regulation of keratinocyte proliferation
platelet alpha granule membrane
transforming growth factor beta binding
regulation of keratinocyte proliferation
syncytium formation by plasma membrane fusion
cell-cell fusion
syncytium formation
regulation of keratinocyte differentiation
osteoclast differentiation
regulation of epidermal cell differentiation
negative regulation of wound healing
hair follicle development
skin epidermis development
negative regulation of transforming growth factor beta receptor signaling pathway
molting cycle process
hair cycle process
negative regulation of cellular response to transforming growth factor beta stimulus
negative regulation of response to wounding
regulation of epidermis development
molting cycle
hair cycle
serine-type endopeptidase inhibitor activity
anchored component of membrane
myeloid leukocyte differentiation
regulation of transforming growth factor beta receptor signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of epithelial cell proliferation
platelet degranulation
regulation of wound healing
regulation of epithelial cell differentiation
negative regulation of cellular response to growth factor stimulus
regulation of response to wounding
myeloid cell differentiation
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of endopeptidase activity
negative regulation of peptidase activity
regulation of cellular response to growth factor stimulus