CD160 [The Human Chemical-Genetic Interaction Map Project]

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======= CD160 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD160
  * **<color #00a2e8>Official Name</color>**: CD160 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11126|11126]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95971|O95971]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD160&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD160|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604463|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor showing broad specificity for both classical and non-classical MHC class I molecules. {ECO:0000269|PubMed:9973372}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activating MHC class I receptor activity|
|negative regulation of T cell costimulation|
|negative regulation of CD4-positive, alpha-beta T cell costimulation|
|regulation of CD4-positive, alpha-beta T cell costimulation|
|negative regulation of adaptive immune memory response|
|regulation of adaptive immune memory response|
|regulation of T cell costimulation|
|MHC class Ib receptor activity|
|MHC class I receptor activity|
|MHC class I protein complex binding|
|positive regulation of natural killer cell mediated immune response to tumor cell|
|positive regulation of natural killer cell cytokine production|
|regulation of natural killer cell cytokine production|
|positive regulation of interferon-gamma secretion|
|regulation of natural killer cell mediated immune response to tumor cell|
|positive regulation of immune response to tumor cell|
|positive regulation of response to tumor cell|
|regulation of interferon-gamma secretion|
|regulation of immune response to tumor cell|
|regulation of response to tumor cell|
|positive regulation of endothelial cell apoptotic process|
|negative regulation of T cell receptor signaling pathway|
|negative regulation of antigen receptor-mediated signaling pathway|
|positive regulation of natural killer cell mediated cytotoxicity|
|mucosal immune response|
|positive regulation of natural killer cell mediated immunity|
|positive regulation of epithelial cell apoptotic process|
|anchored component of plasma membrane|
|organ or tissue specific immune response|
|phosphatidylinositol 3-kinase signaling|
|regulation of T cell receptor signaling pathway|
|regulation of natural killer cell mediated cytotoxicity|
|negative regulation of adaptive immune response|
|regulation of natural killer cell mediated immunity|
|regulation of endothelial cell apoptotic process|
|T cell costimulation|
|positive regulation of cytokine production involved in immune response|
|lymphocyte costimulation|
|positive regulation of leukocyte mediated cytotoxicity|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of antigen receptor-mediated signaling pathway|
|positive regulation of interferon-gamma production|
|positive regulation of cell killing|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|regulation of leukocyte mediated cytotoxicity|
|regulation of epithelial cell apoptotic process|
|defense response to Gram-negative bacterium|
|regulation of cytokine production involved in immune response|
|kinase binding|
|regulation of alpha-beta T cell activation|
|positive regulation of production of molecular mediator of immune response|
|regulation of interferon-gamma production|
|regulation of cell killing|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|positive regulation of lymphocyte mediated immunity|
|negative regulation of vasculature development|
|positive regulation of leukocyte mediated immunity|
|positive regulation of cytokine secretion|
|regulation of production of molecular mediator of immune response|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|regulation of adaptive immune response|
|positive regulation of T cell activation|
|regulation of cytokine secretion|
|regulation of leukocyte mediated immunity|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|positive regulation of cell-cell adhesion|
|positive regulation of protein secretion|
|regulation of angiogenesis|
|positive regulation of peptide secretion|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|angiogenesis|
|regulation of vasculature development|
|defense response to bacterium|
|signaling receptor binding|
|positive regulation of innate immune response|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|blood vessel morphogenesis|
|positive regulation of cell activation|
|positive regulation of protein transport|
|positive regulation of secretion|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|positive regulation of defense response|
|blood vessel development|
|regulation of peptide secretion|
|positive regulation of multi-organism process|
|vasculature development|
|regulation of lymphocyte activation|
|cardiovascular system development|
|regulation of response to biotic stimulus|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|adaptive immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of secretion|
|tube development|
|positive regulation of immune response|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|defense response to other organism|
|positive regulation of transport|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of transport|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.78|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11205
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD160 Expression in NALM6 Cells: 2.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>