CD160
Gene Information
- Official Symbol: CD160
- Official Name: CD160 molecule
- Aliases and Previous Symbols: N/A
- Entrez ID: 11126
- UniProt: O95971
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor showing broad specificity for both classical and non-classical MHC class I molecules. {ECO:0000269|PubMed:9973372}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| activating MHC class I receptor activity |
| negative regulation of T cell costimulation |
| negative regulation of CD4-positive, alpha-beta T cell costimulation |
| regulation of CD4-positive, alpha-beta T cell costimulation |
| negative regulation of adaptive immune memory response |
| regulation of adaptive immune memory response |
| regulation of T cell costimulation |
| MHC class Ib receptor activity |
| MHC class I receptor activity |
| MHC class I protein complex binding |
| positive regulation of natural killer cell mediated immune response to tumor cell |
| positive regulation of natural killer cell cytokine production |
| regulation of natural killer cell cytokine production |
| positive regulation of interferon-gamma secretion |
| regulation of natural killer cell mediated immune response to tumor cell |
| positive regulation of immune response to tumor cell |
| positive regulation of response to tumor cell |
| regulation of interferon-gamma secretion |
| regulation of immune response to tumor cell |
| regulation of response to tumor cell |
| positive regulation of endothelial cell apoptotic process |
| negative regulation of T cell receptor signaling pathway |
| negative regulation of antigen receptor-mediated signaling pathway |
| positive regulation of natural killer cell mediated cytotoxicity |
| mucosal immune response |
| positive regulation of natural killer cell mediated immunity |
| positive regulation of epithelial cell apoptotic process |
| anchored component of plasma membrane |
| organ or tissue specific immune response |
| phosphatidylinositol 3-kinase signaling |
| regulation of T cell receptor signaling pathway |
| regulation of natural killer cell mediated cytotoxicity |
| negative regulation of adaptive immune response |
| regulation of natural killer cell mediated immunity |
| regulation of endothelial cell apoptotic process |
| T cell costimulation |
| positive regulation of cytokine production involved in immune response |
| lymphocyte costimulation |
| positive regulation of leukocyte mediated cytotoxicity |
| regulation of CD4-positive, alpha-beta T cell activation |
| regulation of antigen receptor-mediated signaling pathway |
| positive regulation of interferon-gamma production |
| positive regulation of cell killing |
| phosphatidylinositol-mediated signaling |
| inositol lipid-mediated signaling |
| regulation of leukocyte mediated cytotoxicity |
| regulation of epithelial cell apoptotic process |
| defense response to Gram-negative bacterium |
| regulation of cytokine production involved in immune response |
| kinase binding |
| regulation of alpha-beta T cell activation |
| positive regulation of production of molecular mediator of immune response |
| regulation of interferon-gamma production |
| regulation of cell killing |
| negative regulation of angiogenesis |
| negative regulation of blood vessel morphogenesis |
| positive regulation of lymphocyte mediated immunity |
| negative regulation of vasculature development |
| positive regulation of leukocyte mediated immunity |
| positive regulation of cytokine secretion |
| regulation of production of molecular mediator of immune response |
| negative regulation of immune response |
| regulation of lymphocyte mediated immunity |
| regulation of adaptive immune response |
| positive regulation of T cell activation |
| regulation of cytokine secretion |
| regulation of leukocyte mediated immunity |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| positive regulation of cell-cell adhesion |
| positive regulation of protein secretion |
| regulation of angiogenesis |
| positive regulation of peptide secretion |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| angiogenesis |
| regulation of vasculature development |
| defense response to bacterium |
| signaling receptor binding |
| positive regulation of innate immune response |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of secretion by cell |
| blood vessel morphogenesis |
| positive regulation of cell activation |
| positive regulation of protein transport |
| positive regulation of secretion |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| regulation of innate immune response |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of immune effector process |
| positive regulation of defense response |
| blood vessel development |
| regulation of peptide secretion |
| positive regulation of multi-organism process |
| vasculature development |
| regulation of lymphocyte activation |
| cardiovascular system development |
| regulation of response to biotic stimulus |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| adaptive immune response |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| tube morphogenesis |
| regulation of cell adhesion |
| response to bacterium |
| regulation of cytokine production |
| positive regulation of cell death |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| regulation of secretion |
| tube development |
| positive regulation of immune response |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| negative regulation of developmental process |
| defense response to other organism |
| positive regulation of transport |
| regulation of protein localization |
| regulation of anatomical structure morphogenesis |
| regulation of response to external stimulus |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of response to stress |
| regulation of apoptotic process |
| regulation of programmed cell death |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| regulation of transport |
| immune response |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Oligomycin-A 20μM R00 exp26 | -1.78 |
| HMS-I2 10μM R06 exp288 | 1.71 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11205
- Expression level (log2 read counts): 2.14
Expression Distribution
CD160 Expression in NALM6 Cells: 2.14
