CD180

Entrez Summary: N/A
UniProt Summary: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

B cell proliferation involved in immune response
positive regulation of lipopolysaccharide-mediated signaling pathway
regulation of lipopolysaccharide-mediated signaling pathway
B cell proliferation
B cell activation involved in immune response
lymphocyte proliferation
mononuclear cell proliferation
leukocyte proliferation
lymphocyte activation involved in immune response
B cell activation
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
cellular response to biotic stimulus
extracellular matrix
response to lipopolysaccharide
response to molecule of bacterial origin
positive regulation of response to biotic stimulus
lymphocyte activation
inflammatory response
positive regulation of multi-organism process
cellular response to lipid
regulation of response to biotic stimulus
cell population proliferation
positive regulation of response to external stimulus
leukocyte activation involved in immune response
cell activation involved in immune response
response to bacterium
innate immune response
regulation of multi-organism process
response to lipid
leukocyte activation
defense response to other organism
cellular response to oxygen-containing compound
cell activation
immune effector process
regulation of response to external stimulus
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response