CD1C [The Human Chemical-Genetic Interaction Map Project]

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======= CD1C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD1C
  * **<color #00a2e8>Official Name</color>**: CD1c molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=911|911]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29017|P29017]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD1C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD1C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/188340|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269|PubMed:10786796, ECO:0000269|PubMed:10890914, ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:21167756}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycolipid binding|
|endogenous lipid antigen binding|
|exogenous lipid antigen binding|
|antigen processing and presentation, endogenous lipid antigen via MHC class Ib|
|antigen processing and presentation, exogenous lipid antigen via MHC class Ib|
|antigen processing and presentation of lipid antigen via MHC class Ib|
|lipopeptide binding|
|antigen processing and presentation via MHC class Ib|
|antigen processing and presentation of endogenous antigen|
|positive regulation of T cell mediated cytotoxicity|
|regulation of T cell mediated cytotoxicity|
|positive regulation of T cell mediated immunity|
|positive regulation of leukocyte mediated cytotoxicity|
|T cell activation involved in immune response|
|positive regulation of cell killing|
|regulation of T cell mediated immunity|
|regulation of leukocyte mediated cytotoxicity|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cell killing|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|lymphocyte activation involved in immune response|
|positive regulation of leukocyte mediated immunity|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|regulation of adaptive immune response|
|antigen processing and presentation of exogenous antigen|
|regulation of leukocyte mediated immunity|
|endosome membrane|
|antigen processing and presentation|
|positive regulation of immune effector process|
|T cell activation|
|lysosome|
|lymphocyte activation|
|external side of plasma membrane|
|regulation of immune effector process|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|positive regulation of immune response|
|leukocyte activation|
|cell activation|
|immune effector process|
|regulation of immune response|
|positive regulation of immune system process|
|integral component of plasma membrane|
|extracellular space|
|regulation of immune system process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.85|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.79|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.72|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16266
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD1C Expression in NALM6 Cells: -0.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>