CD1C

Gene Information

Official Symbol: CD1C
Official Name: CD1c molecule
Aliases and Previous Symbols: N/A
Entrez ID: 911
UniProt: P29017
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269|PubMed:10786796, ECO:0000269|PubMed:10890914, ECO:0000269|PubMed:10899914, ECO:0000269|PubMed:21167756}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Etoposide 0.3μM R05 exp199	-1.85
Calcium Ionophore 0.4μM R07 exp342	-1.79
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.72
Ribavirin 10 to 15μM on day4 R04 exp160	2.25

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16266
Expression level (log2 read counts): -0.36

Expression Distribution

glycolipid binding
endogenous lipid antigen binding
exogenous lipid antigen binding
antigen processing and presentation, endogenous lipid antigen via MHC class Ib
antigen processing and presentation, exogenous lipid antigen via MHC class Ib
antigen processing and presentation of lipid antigen via MHC class Ib
lipopeptide binding
antigen processing and presentation via MHC class Ib
antigen processing and presentation of endogenous antigen
positive regulation of T cell mediated cytotoxicity
regulation of T cell mediated cytotoxicity
positive regulation of T cell mediated immunity
positive regulation of leukocyte mediated cytotoxicity
T cell activation involved in immune response
positive regulation of cell killing
regulation of T cell mediated immunity
regulation of leukocyte mediated cytotoxicity
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of cell killing
positive regulation of lymphocyte mediated immunity
positive regulation of adaptive immune response
lymphocyte activation involved in immune response
positive regulation of leukocyte mediated immunity
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of lymphocyte mediated immunity
regulation of adaptive immune response
antigen processing and presentation of exogenous antigen
regulation of leukocyte mediated immunity
endosome membrane
antigen processing and presentation
positive regulation of immune effector process
T cell activation
lysosome
lymphocyte activation
external side of plasma membrane
regulation of immune effector process
adaptive immune response
leukocyte activation involved in immune response
cell activation involved in immune response
positive regulation of immune response