CD200R1

Gene Information

Official Symbol: CD200R1
Official Name: CD200 receptor 1
Aliases and Previous Symbols: N/A
Entrez ID: 131450
UniProt: Q8TD46
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. {ECO:0000269|PubMed:12960329}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18822
Expression level (log2 read counts): 0.31

Expression Distribution

immunoglobulin receptor activity
glycosylated region protein binding
negative regulation of T cell migration
negative regulation of macrophage migration
negative regulation of interleukin-6 secretion
negative regulation of neuroinflammatory response
negative regulation of lymphocyte migration
regulation of neuroinflammatory response
heterotypic cell-cell adhesion
regulation of macrophage migration
negative regulation of interleukin-6 production
regulation of T cell migration
negative regulation of leukocyte migration
regulation of lymphocyte migration
negative regulation of cytokine secretion
negative regulation of protein secretion
negative regulation of inflammatory response
negative regulation of peptide secretion
regulation of interleukin-6 production
negative regulation of protein transport
negative regulation of establishment of protein localization
regulation of leukocyte migration
negative regulation of secretion by cell
signaling receptor activity
receptor complex
regulation of cytokine secretion
negative regulation of neuron death
negative regulation of defense response
negative regulation of secretion
Fc receptor signaling pathway
negative regulation of cell migration
negative regulation of cytokine production
negative regulation of cell motility
negative regulation of cellular component movement
regulation of neuron death
negative regulation of locomotion
regulation of inflammatory response
negative regulation of response to external stimulus
external side of plasma membrane
negative regulation of immune system process