CD226

Gene Information

Official Symbol: CD226
Official Name: CD226 molecule
Aliases and Previous Symbols: N/A
Entrez ID: 10666
UniProt: Q15762
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T- cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:8673704}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12693
Expression level (log2 read counts): 3.46

Expression Distribution

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
positive regulation of natural killer cell cytokine production
positive regulation of natural killer cell mediated immune response to tumor cell
positive regulation of Fc receptor mediated stimulatory signaling pathway
regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
regulation of natural killer cell cytokine production
regulation of natural killer cell mediated immune response to tumor cell
positive regulation of response to tumor cell
positive regulation of immune response to tumor cell
regulation of Fc receptor mediated stimulatory signaling pathway
regulation of response to tumor cell
regulation of immune response to tumor cell
positive regulation of T cell receptor signaling pathway
positive regulation of mast cell activation
positive regulation of antigen receptor-mediated signaling pathway
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated immunity
positive regulation of immunoglobulin mediated immune response
positive regulation of B cell mediated immunity
regulation of T cell receptor signaling pathway
regulation of natural killer cell mediated cytotoxicity
regulation of natural killer cell mediated immunity
regulation of mast cell activation
regulation of B cell mediated immunity
regulation of immunoglobulin mediated immune response
positive regulation of cytokine production involved in immune response
positive regulation of leukocyte mediated cytotoxicity
cell adhesion molecule binding
regulation of antigen receptor-mediated signaling pathway
positive regulation of interferon-gamma production
positive regulation of cell killing
regulation of leukocyte mediated cytotoxicity
regulation of cytokine production involved in immune response
positive regulation of production of molecular mediator of immune response
regulation of interferon-gamma production
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of cell killing
positive regulation of lymphocyte mediated immunity
positive regulation of adaptive immune response
integrin binding