CD320

Entrez Summary: This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011].
UniProt Summary: Receptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389). Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213). Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells (PubMed:10727470). Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation (PubMed:10727470, PubMed:11418631). Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) (PubMed:11418631). CD320 augments the proliferation of PC precursors generated by IL-10 (PubMed:11418631). {ECO:0000269|PubMed:10727470, ECO:0000269|PubMed:11418631, ECO:0000269|PubMed:18779389, ECO:0000269|PubMed:20524213}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ATPase-coupled vitamin B12 transmembrane transporter activity
B cell costimulation
cobalamin transport
cobalamin binding
regulation of vitamin metabolic process
cobalamin metabolic process
vitamin transport
positive regulation of B cell proliferation
cofactor transport
lymphocyte costimulation
tetrapyrrole metabolic process
regulation of B cell proliferation
water-soluble vitamin metabolic process
vitamin metabolic process
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
positive regulation of leukocyte proliferation
drug transport
growth factor activity
positive regulation of B cell activation
regulation of B cell activation
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
endosome membrane
regulation of leukocyte proliferation
positive regulation of lymphocyte activation
positive regulation of leukocyte activation
positive regulation of cell activation
regulation of small molecule metabolic process
cofactor metabolic process
drug metabolic process
regulation of lymphocyte activation
regulation of leukocyte activation
regulation of cell activation
calcium ion binding
positive regulation of cell population proliferation
endoplasmic reticulum
response to drug
positive regulation of immune system process
integral component of plasma membrane