CD3G

Gene Information

Official Symbol: CD3G
Official Name: CD3g molecule
Aliases and Previous Symbols: N/A
Entrez ID: 917
UniProt: P09693
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008].
UniProt Summary: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface (PubMed:8187769). Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G. {ECO:0000269|PubMed:2470098, ECO:0000269|PubMed:8187769, ECO:0000269|PubMed:8636209}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11767
Expression level (log2 read counts): 3.18

Expression Distribution

alpha-beta T cell receptor complex
T cell receptor binding
positive thymic T cell selection
thymic T cell selection
receptor signaling complex adaptor activity
positive T cell selection
T cell selection
T cell differentiation in thymus
regulation of lymphocyte apoptotic process
clathrin-coated vesicle membrane
regulation of leukocyte apoptotic process
T cell receptor complex
T cell differentiation
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
Fc-gamma receptor signaling pathway involved in phagocytosis
transmembrane signaling receptor activity
Fc receptor mediated stimulatory signaling pathway
Fc-gamma receptor signaling pathway
T cell receptor signaling pathway
establishment or maintenance of cell polarity
T cell activation
lymphocyte differentiation
Fc receptor signaling pathway
antigen receptor-mediated signaling pathway
phagocytosis
leukocyte differentiation
protein homooligomerization
lymphocyte activation
external side of plasma membrane
immune response-activating cell surface receptor signaling pathway
immune response-regulating cell surface receptor signaling pathway
protein heterodimerization activity
protein complex oligomerization
hemopoiesis
immune response-activating signal transduction
immune response-regulating signaling pathway
hematopoietic or lymphoid organ development
adaptive immune response
activation of immune response
immune system development