CD44
Gene Information
- Official Symbol: CD44
- Official Name: CD44 molecule (Indian blood group)
- Aliases and Previous Symbols: N/A
- Entrez ID: 960
- UniProt: P16070
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record represents the CD44*001.1.1 allele.
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Xlink |
GO Terms
| macrophage migration inhibitory factor receptor complex |
| positive regulation of monocyte aggregation |
| monocyte aggregation |
| regulation of monocyte aggregation |
| leukocyte aggregation |
| regulation of lamellipodium morphogenesis |
| negative regulation of DNA damage response, signal transduction by p53 class mediator |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| hyaluronan catabolic process |
| positive regulation of heterotypic cell-cell adhesion |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| lamellipodium membrane |
| hyaluronic acid binding |
| epiboly involved in wound healing |
| wound healing, spreading of cells |
| regulation of heterotypic cell-cell adhesion |
| epiboly |
| regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| hyaluronan metabolic process |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| negative regulation of signal transduction by p53 class mediator |
| regulation of DNA damage response, signal transduction by p53 class mediator |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| regulation of lamellipodium organization |
| cytokine receptor activity |
| morphogenesis of an epithelial sheet |
| leukocyte cell-cell adhesion |
| glycosaminoglycan catabolic process |
| microvillus |
| collagen binding |
| extracellular matrix disassembly |
| aminoglycan catabolic process |
| interferon-gamma-mediated signaling pathway |
| negative regulation of response to DNA damage stimulus |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of cysteine-type endopeptidase activity |
| negative regulation of intrinsic apoptotic signaling pathway |
| cell projection |
| secretory granule membrane |
| positive regulation of peptidyl-serine phosphorylation |
| mucopolysaccharide metabolic process |
| cellular response to fibroblast growth factor stimulus |
| response to fibroblast growth factor |
| cell-matrix adhesion |
| transmembrane signaling receptor activity |
| regulation of peptidyl-serine phosphorylation |
| glycosaminoglycan metabolic process |
| regulation of intrinsic apoptotic signaling pathway |
| cellular response to interferon-gamma |
| aminoglycan metabolic process |
| cartilage development |
| regulation of signal transduction by p53 class mediator |
| response to interferon-gamma |
| cell-substrate adhesion |
| positive regulation of peptidyl-tyrosine phosphorylation |
| carbohydrate derivative catabolic process |
| basolateral plasma membrane |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of leukocyte cell-cell adhesion |
| regulation of response to DNA damage stimulus |
| connective tissue development |
| negative regulation of apoptotic signaling pathway |
| T cell activation |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of cell-cell adhesion |
| negative regulation of peptidase activity |
| carboxylic acid catabolic process |
| organic acid catabolic process |
| regulation of ERK1 and ERK2 cascade |
| regulation of leukocyte cell-cell adhesion |
| apical plasma membrane |
| extracellular matrix organization |
| negative regulation of proteolysis |
| leukocyte migration |
| lymphocyte activation |
| extracellular structure organization |
| regulation of apoptotic signaling pathway |
| regulation of cell-cell adhesion |
| cellular component disassembly |
| positive regulation of cell adhesion |
| focal adhesion |
| regulation of endopeptidase activity |
| morphogenesis of an epithelium |
| small molecule catabolic process |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| wound healing |
| neutrophil degranulation |
| regulation of cell morphogenesis |
| neutrophil activation involved in immune response |
| skeletal system development |
| inflammatory response |
| neutrophil mediated immunity |
| cellular response to growth factor stimulus |
| neutrophil activation |
| cell-cell adhesion |
| granulocyte activation |
| negative regulation of intracellular signal transduction |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| response to growth factor |
| positive regulation of MAPK cascade |
| tissue morphogenesis |
| response to wounding |
| myeloid leukocyte activation |
| cell surface |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| regulation of plasma membrane bounded cell projection organization |
| regulated exocytosis |
| regulation of cell projection organization |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| innate immune response |
| leukocyte mediated immunity |
| negative regulation of catalytic activity |
| exocytosis |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| carboxylic acid metabolic process |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| defense response to other organism |
| cell migration |
| Golgi apparatus |
| negative regulation of cell death |
| oxoacid metabolic process |
| secretion by cell |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| negative regulation of cellular protein metabolic process |
| export from cell |
| macromolecule catabolic process |
| positive regulation of phosphorylation |
| organonitrogen compound catabolic process |
| regulation of anatomical structure morphogenesis |
| cell activation |
| localization of cell |
| cell motility |
| immune effector process |
| response to cytokine |
| negative regulation of protein metabolic process |
| epithelium development |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| integral component of plasma membrane |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| small molecule metabolic process |
| tissue development |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| immune response |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14822
- Expression level (log2 read counts): -0.87
Expression Distribution
CD44 Expression in NALM6 Cells: -0.87
