CD83

Gene Information

Official Symbol: CD83
Official Name: CD83 molecule
Aliases and Previous Symbols: N/A
Entrez ID: 9308
UniProt: Q01151
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5326
Expression level (log2 read counts): 3.58

Expression Distribution

negative regulation of interleukin-4 production
regulation of interleukin-4 production
positive regulation of CD4-positive, alpha-beta T cell differentiation
positive regulation of interleukin-2 production
positive regulation of CD4-positive, alpha-beta T cell activation
positive regulation of interleukin-10 production
regulation of CD4-positive, alpha-beta T cell differentiation
positive regulation of alpha-beta T cell differentiation
regulation of interleukin-10 production
regulation of interleukin-2 production
positive regulation of alpha-beta T cell activation
regulation of CD4-positive, alpha-beta T cell activation
regulation of alpha-beta T cell differentiation
positive regulation of T cell differentiation
regulation of alpha-beta T cell activation
positive regulation of lymphocyte differentiation
regulation of T cell differentiation
positive regulation of leukocyte differentiation
regulation of lymphocyte differentiation
positive regulation of hemopoiesis
positive regulation of T cell activation
positive regulation of leukocyte cell-cell adhesion
positive regulation of cell-cell adhesion
regulation of leukocyte differentiation
negative regulation of cytokine production
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
humoral immune response
positive regulation of lymphocyte activation
external side of plasma membrane
regulation of cell-cell adhesion
positive regulation of leukocyte activation
positive regulation of cell adhesion
positive regulation of cell activation
positive regulation of cytokine production
regulation of hemopoiesis
regulation of lymphocyte activation
regulation of leukocyte activation
regulation of cell activation
regulation of cell adhesion