CDA
Gene Information
- Official Symbol: CDA
- Official Name: cytidine deaminase
- Aliases and Previous Symbols: N/A
- Entrez ID: 978
- UniProt: P32320
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Pfam Domains GO Terms
Pfam Domains
| dCMP cyt deam 2 |
| dCMP cyt deam 1 |
GO Terms
| cytosine metabolic process |
| nucleoside binding |
| pyrimidine nucleoside salvage |
| pyrimidine-containing compound salvage |
| cytidine metabolic process |
| cytidine catabolic process |
| cytidine deaminase activity |
| cytidine deamination |
| pyrimidine ribonucleoside catabolic process |
| pyrimidine ribonucleoside metabolic process |
| nucleoside salvage |
| pyrimidine nucleoside biosynthetic process |
| negative regulation of nucleotide metabolic process |
| pyrimidine nucleobase metabolic process |
| ribonucleoside catabolic process |
| pyrimidine nucleoside catabolic process |
| nucleoside catabolic process |
| cellular metabolic compound salvage |
| pyrimidine nucleoside metabolic process |
| nucleoside biosynthetic process |
| nucleobase metabolic process |
| glycosyl compound biosynthetic process |
| pyrimidine-containing compound catabolic process |
| glycosyl compound catabolic process |
| nucleobase-containing small molecule catabolic process |
| tertiary granule lumen |
| pyrimidine-containing compound biosynthetic process |
| ribonucleoside metabolic process |
| negative regulation of small molecule metabolic process |
| protein homotetramerization |
| pyrimidine-containing compound metabolic process |
| nucleobase-containing small molecule biosynthetic process |
| nucleoside metabolic process |
| secretory granule lumen |
| regulation of nucleotide metabolic process |
| ficolin-1-rich granule lumen |
| glycosyl compound metabolic process |
| protein tetramerization |
| negative regulation of cell growth |
| carbohydrate derivative catabolic process |
| negative regulation of growth |
| protein homooligomerization |
| nucleobase-containing compound catabolic process |
| regulation of cell growth |
| regulation of small molecule metabolic process |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| small molecule catabolic process |
| aromatic compound catabolic process |
| organic cyclic compound catabolic process |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| protein complex oligomerization |
| myeloid cell activation involved in immune response |
| nucleobase-containing small molecule metabolic process |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| myeloid leukocyte activation |
| small molecule biosynthetic process |
| carbohydrate derivative biosynthetic process |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of growth |
| regulated exocytosis |
| leukocyte mediated immunity |
| exocytosis |
| zinc ion binding |
| protein homodimerization activity |
| leukocyte activation |
| secretion by cell |
| carbohydrate derivative metabolic process |
| export from cell |
| organonitrogen compound catabolic process |
| cell activation |
| immune effector process |
| nucleobase-containing compound biosynthetic process |
| secretion |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| protein-containing complex assembly |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| protein-containing complex subunit organization |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| L-BMAA 500 to 750μM on day4 R04 exp185 | -1.92 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10194
- Expression level (log2 read counts): -7.68
Expression Distribution
CDA Expression in NALM6 Cells: -7.68
