CDC42BPA

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
All-trans-Retinoic-Acid 8μM R07 exp333	-2.04
Trientine 500μM R08 exp534	-1.76
BI-6727 0.0125μM R03 exp97	1.7
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	1.73
Phenformin 20μM R03 exp143	1.81
SGC2043 10μM R03 exp152	1.95
Oligomycin-A 2μM R00 exp25	2.2

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

actomyosin
cell leading edge
actin cytoskeleton reorganization
peptidyl-threonine phosphorylation
peptidyl-threonine modification
actomyosin structure organization
cell-cell junction
lamellipodium
magnesium ion binding
protein serine/threonine kinase activity
cytoskeleton
actin cytoskeleton organization
actin filament-based process
peptidyl-amino acid modification
cell migration
protein phosphorylation
identical protein binding
cell motility
localization of cell
cytoskeleton organization
phosphorylation
locomotion
ATP binding
movement of cell or subcellular component
intracellular signal transduction