CDC42EP5

Gene Information

Official Symbol: CDC42EP5
Official Name: CDC42 effector protein 5
Aliases and Previous Symbols: N/A
Entrez ID: 148170
UniProt: Q6NZY7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6600
Expression level (log2 read counts): -5.01

Expression Distribution

positive regulation of pseudopodium assembly
regulation of pseudopodium assembly
GTP-Rho binding
endomembrane system
Rho protein signal transduction
JNK cascade
positive regulation of actin filament polymerization
positive regulation of plasma membrane bounded cell projection assembly
stress-activated MAPK cascade
positive regulation of protein polymerization
stress-activated protein kinase signaling cascade
regulation of cell shape
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of supramolecular fiber organization
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
positive regulation of cytoskeleton organization
regulation of protein polymerization
Ras protein signal transduction
positive regulation of protein complex assembly
regulation of actin filament organization
small GTPase mediated signal transduction
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
cytoskeleton
MAPK cascade
regulation of cellular component size
positive regulation of cell projection organization
regulation of actin filament-based process
signal transduction by protein phosphorylation
regulation of protein complex assembly
regulation of cell morphogenesis
regulation of anatomical structure size
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
positive regulation of organelle organization
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization