CDC45 [The Human Chemical-Genetic Interaction Map Project]

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======= CDC45 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDC45
  * **<color #00a2e8>Official Name</color>**: cell division cycle 45
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8318|8318]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75419|O75419]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDC45&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDC45|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603465|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for initiation of chromosomal DNA replication.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CDC45|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic DNA replication preinitiation complex assembly|
|DNA replication preinitiation complex|
|regulation of chromatin silencing at telomere|
|DNA replication preinitiation complex assembly|
|nuclear pre-replicative complex|
|replication fork protection complex|
|mitotic DNA replication|
|double-strand break repair via break-induced replication|
|DNA replication checkpoint|
|3-5 DNA helicase activity|
|DNA replication origin binding|
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|DNA replication initiation|
|positive regulation of G1/S transition of mitotic cell cycle|
|regulation of chromatin silencing|
|nuclear DNA replication|
|cell cycle DNA replication|
|positive regulation of cell cycle G1/S phase transition|
|positive regulation of mitotic cell cycle phase transition|
|positive regulation of cell cycle phase transition|
|double-strand break repair via homologous recombination|
|recombinational repair|
|single-stranded DNA binding|
|DNA duplex unwinding|
|G1/S transition of mitotic cell cycle|
|DNA geometric change|
|cell cycle G1/S phase transition|
|DNA-dependent DNA replication|
|regulation of gene silencing|
|DNA integrity checkpoint|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|regulation of cell cycle G1/S phase transition|
|double-strand break repair|
|regulation of chromatin organization|
|cell cycle checkpoint|
|protein-DNA complex assembly|
|DNA replication|
|DNA recombination|
|protein-DNA complex subunit organization|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|positive regulation of cell cycle process|
|DNA conformation change|
|regulation of chromosome organization|
|positive regulation of cell cycle|
|chromatin binding|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|centrosome|
|DNA repair|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|cellular protein-containing complex assembly|
|cell cycle process|
|chromosome organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|protein-containing complex assembly|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.43|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.09|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.06|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.96|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.85|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.7|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.7|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.73|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.74|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.76|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.78|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.78|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.79|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.82|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.83|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.88|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.89|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.9|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.91|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.95|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.97|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.99|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|2.01|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|2.04|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.06|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.09|
|[[:results:exp218|A-395 10μM R05 exp218]]|2.12|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|2.12|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.18|
|[[:results:exp292|Menadione 5μM R06 exp292]]|2.18|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.18|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.2|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|2.26|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.27|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|2.34|
|[[:results:exp483|FTY720 3μM R08 exp483]]|2.36|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.42|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.42|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|2.58|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|2.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.571|
|[[:human genes:p:psma6|PSMA6]]|0.559|
|[[:human genes:t:twistnb|TWISTNB]]|0.543|
|[[:human genes:c:cbwd5|CBWD5]]|0.543|
|[[:human genes:c:ccna2|CCNA2]]|0.541|
|[[:human genes:t:tspy8|TSPY8]]|0.528|
|[[:human genes:c:cbwd3|CBWD3]]|0.526|
|[[:human genes:p:polr2j3|POLR2J3]]|0.522|
|[[:human genes:u:upf1|UPF1]]|0.52|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.518|
|[[:human genes:t:tfip11|TFIP11]]|0.516|
|[[:human genes:p:psmd1|PSMD1]]|0.514|
|[[:human genes:u:utp20|UTP20]]|0.514|
|[[:human genes:a:acsf2|ACSF2]]|0.511|
|[[:human genes:s:slc4a1|SLC4A1]]|0.506|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.503|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.5|
|[[:human genes:z:znf830|ZNF830]]|0.494|
|[[:human genes:r:rrp7a|RRP7A]]|0.492|
|[[:human genes:c:chmp4b|CHMP4B]]|0.492|
|[[:human genes:t:tceb3c|TCEB3C]]|0.489|
|[[:human genes:s:syt9|SYT9]]|0.487|
|[[:human genes:c:cbwd6|CBWD6]]|0.487|
|[[:human genes:r:rad21|RAD21]]|0.487|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.486|
|[[:human genes:n:nupl1|NUPL1]]|0.486|
|[[:human genes:w:wdr43|WDR43]]|0.482|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.482|
|[[:human genes:i:ik|IK]]|0.482|
|[[:human genes:r:rps12|RPS12]]|0.479|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.479|
|[[:human genes:p:pole|POLE]]|0.477|
|[[:human genes:n:nup160|NUP160]]|0.477|
|[[:human genes:s:supt5h|SUPT5H]]|0.475|
|[[:human genes:r:rrp15|RRP15]]|0.474|
|[[:human genes:w:wdr75|WDR75]]|0.473|
|[[:human genes:h:hap1|HAP1]]|0.471|
|[[:human genes:l:lrr1|LRR1]]|0.471|
|[[:human genes:p:psmb3|PSMB3]]|0.471|
|[[:human genes:s:ssh2|SSH2]]|0.47|
|[[:human genes:p:psma1|PSMA1]]|0.47|
|[[:human genes:c:ccdc116|CCDC116]]|0.469|
|[[:human genes:p:psmd3|PSMD3]]|0.468|
|[[:human genes:k:kctd17|KCTD17]]|0.467|
|[[:human genes:d:dock6|DOCK6]]|0.466|
|[[:human genes:a:aatf|AATF]]|0.465|
|[[:human genes:p:pwp2|PWP2]]|0.464|
|[[:human genes:v:vasn|VASN]]|0.462|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.462|
|[[:human genes:p:psmc2|PSMC2]]|0.462|
|[[:human genes:p:pola2|POLA2]]|0.462|
|[[:human genes:m:mt1e|MT1E]]|0.462|
|[[:human genes:c:chchd3|CHCHD3]]|0.461|
|[[:human genes:r:rps2|RPS2]]|0.461|
|[[:human genes:p:psmb2|PSMB2]]|0.461|
|[[:human genes:r:rrn3|RRN3]]|0.458|
|[[:human genes:e:exosc5|EXOSC5]]|0.457|
|[[:human genes:m:med17|MED17]]|0.457|
|[[:human genes:z:zfand5|ZFAND5]]|0.456|
|[[:human genes:c:cope|COPE]]|0.454|
|[[:human genes:d:ddtl|DDTL]]|0.454|
|[[:human genes:s:sec13|SEC13]]|0.454|
|[[:human genes:r:rad51|RAD51]]|0.453|
|[[:human genes:o:or10g3|OR10G3]]|0.453|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.452|
|[[:human genes:s:supt6h|SUPT6H]]|0.451|
|[[:human genes:o:ogfr|OGFR]]|0.451|
|[[:human genes:t:traip|TRAIP]]|0.45|
|[[:human genes:m:myo1h|MYO1H]]|0.448|
|[[:human genes:p:psma7|PSMA7]]|0.447|
|[[:human genes:i:iscu|ISCU]]|0.445|
|[[:human genes:k:krt78|KRT78]]|0.445|
|[[:human genes:f:fam25b|FAM25B]]|0.445|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.444|
|[[:human genes:n:nbpf10|NBPF10]]|0.443|
|[[:human genes:c:col2a1|COL2A1]]|0.442|
|[[:human genes:r:rpl35|RPL35]]|0.442|
|[[:human genes:n:nbpf16|NBPF16]]|0.441|
|[[:human genes:t:ticrr|TICRR]]|0.439|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.439|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.439|
|[[:human genes:a:arcn1|ARCN1]]|0.437|
|[[:human genes:s:stil|STIL]]|0.436|
|[[:human genes:c:cactin|CACTIN]]|0.436|
|[[:human genes:a:akirin2|AKIRIN2]]|0.436|
|[[:human genes:c:cdc6|CDC6]]|0.436|
|[[:human genes:r:rfxank|RFXANK]]|0.436|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.435|
|[[:human genes:p:polr2d|POLR2D]]|0.435|
|[[:human genes:c:copg1|COPG1]]|0.433|
|[[:human genes:e:exosc9|EXOSC9]]|0.432|
|[[:human genes:c:ccdc94|CCDC94]]|0.432|
|[[:human genes:r:rps5|RPS5]]|0.432|
|[[:human genes:p:psmc6|PSMC6]]|0.431|
|[[:human genes:r:ranbp2|RANBP2]]|0.431|
|[[:human genes:x:xab2|XAB2]]|0.43|
|[[:human genes:o:orc6|ORC6]]|0.429|
|[[:human genes:c:chd4|CHD4]]|0.429|
|[[:human genes:n:npipb8|NPIPB8]]|0.428|
|[[:human genes:p:pola1|POLA1]]|0.428|
|[[:human genes:t:ttc31|TTC31]]|0.428|
|[[:human genes:g:golga6a|GOLGA6A]]|0.427|
|[[:human genes:p:psmd11|PSMD11]]|0.427|
|[[:human genes:n:npipb5|NPIPB5]]|0.427|
|[[:human genes:r:rps3a|RPS3A]]|0.426|
|[[:human genes:s:slc38a7|SLC38A7]]|0.426|
|[[:human genes:d:disp2|DISP2]]|0.426|
|[[:human genes:o:osbp|OSBP]]|0.426|
|[[:human genes:s:sart1|SART1]]|0.423|
|[[:human genes:r:rbbp5|RBBP5]]|0.423|
|[[:human genes:e:eif4a3|EIF4A3]]|0.422|
|[[:human genes:c:copz1|COPZ1]]|0.422|
|[[:human genes:p:plk4|PLK4]]|0.422|
|[[:human genes:m:myb|MYB]]|0.421|
|[[:human genes:t:timeless|TIMELESS]]|0.421|
|[[:human genes:f:fam160a1|FAM160A1]]|0.421|
|[[:human genes:c:cmya5|CMYA5]]|0.42|
|[[:human genes:n:nfatc4|NFATC4]]|0.42|
|[[:human genes:c:cep192|CEP192]]|0.42|
|[[:human genes:r:rpl9|RPL9]]|0.42|
|[[:human genes:t:ttc1|TTC1]]|0.42|
|[[:human genes:r:rps28|RPS28]]|0.419|
|[[:human genes:n:nup43|NUP43]]|0.419|
|[[:human genes:n:nup153|NUP153]]|0.418|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.417|
|[[:human genes:w:wdr87|WDR87]]|0.417|
|[[:human genes:g:golga8o|GOLGA8O]]|0.417|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.417|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.416|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.416|
|[[:human genes:t:trappc8|TRAPPC8]]|0.416|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.416|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.416|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.416|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.416|
|[[:human genes:m:mat2a|MAT2A]]|0.415|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.415|
|[[:human genes:r:riok2|RIOK2]]|0.415|
|[[:human genes:f:fam231a|FAM231A]]|0.415|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.415|
|[[:human genes:f:fam231c|FAM231C]]|0.415|
|[[:human genes:a:aqr|AQR]]|0.415|
|[[:human genes:s:sel1l|SEL1L]]|0.412|
|[[:human genes:l:lad1|LAD1]]|0.411|
|[[:human genes:s:smg1|SMG1]]|0.411|
|[[:human genes:r:rangap1|RANGAP1]]|0.411|
|[[:human genes:d:dhx38|DHX38]]|0.41|
|[[:human genes:r:rps14|RPS14]]|0.409|
|[[:human genes:t:top1mt|TOP1MT]]|0.409|
|[[:human genes:r:rilpl2|RILPL2]]|0.409|
|[[:human genes:s:slc6a17|SLC6A17]]|0.409|
|[[:human genes:n:nup107|NUP107]]|0.408|
|[[:human genes:s:snip1|SNIP1]]|0.408|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.408|
|[[:human genes:a:atp13a1|ATP13A1]]|0.407|
|[[:human genes:g:gid4|GID4]]|0.406|
|[[:human genes:c:chaf1a|CHAF1A]]|0.406|
|[[:human genes:u:ubl5|UBL5]]|0.406|
|[[:human genes:s:snrpa1|SNRPA1]]|0.406|
|[[:human genes:u:utp3|UTP3]]|0.406|
|[[:human genes:r:rpl30|RPL30]]|0.406|
|[[:human genes:m:mms22l|MMS22L]]|0.405|
|[[:human genes:n:nol12|NOL12]]|0.405|
|[[:human genes:b:brf2|BRF2]]|0.405|
|[[:human genes:p:plk1|PLK1]]|0.405|
|[[:human genes:d:ddt|DDT]]|0.405|
|[[:human genes:r:rnpc3|RNPC3]]|0.405|
|[[:human genes:p:pop1|POP1]]|0.404|
|[[:human genes:v:vps54|VPS54]]|0.404|
|[[:human genes:t:tonsl|TONSL]]|0.404|
|[[:human genes:o:orc1|ORC1]]|0.404|
|[[:human genes:a:ankle1|ANKLE1]]|0.404|
|[[:human genes:d:dtl|DTL]]|0.403|
|[[:human genes:n:narfl|NARFL]]|0.403|
|[[:human genes:r:rpl34|RPL34]]|0.403|
|[[:human genes:p:pcf11|PCF11]]|0.402|
|[[:human genes:a:ankle2|ANKLE2]]|0.402|
|[[:human genes:p:psmc1|PSMC1]]|0.402|
|[[:human genes:a:acbd4|ACBD4]]|0.401|
|[[:human genes:a:ahctf1|AHCTF1]]|0.401|
|[[:human genes:c:cgb2|CGB2]]|0.401|
|[[:human genes:p:psmd7|PSMD7]]|0.401|
|[[:human genes:g:golga6b|GOLGA6B]]|0.401|
|[[:human genes:p:psmc4|PSMC4]]|0.4|
|[[:human genes:i:igfn1|IGFN1]]|0.4|
|[[:human genes:n:nsf|NSF]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 738/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 110
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDC45 Expression in NALM6 Cells: 6.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>