CDH17 [The Human Chemical-Genetic Interaction Map Project]

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======= CDH17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDH17
  * **<color #00a2e8>Official Name</color>**: cadherin 17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1015|1015]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12864|Q12864]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDH17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDH17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603017|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. {ECO:0000269|PubMed:8153632}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proton-dependent oligopeptide secondary active transmembrane transporter activity|
|positive regulation of integrin activation by cell surface receptor linked signal transduction|
|germinal center B cell differentiation|
|positive regulation of integrin activation|
|oligopeptide transmembrane transport|
|oligopeptide transport|
|marginal zone B cell differentiation|
|regulation of integrin activation|
|mature B cell differentiation involved in immune response|
|mature B cell differentiation|
|cell-cell adhesion mediated by cadherin|
|catenin complex|
|spleen development|
|transporter activity|
|B cell activation involved in immune response|
|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|
|cytoskeletal protein binding|
|adherens junction organization|
|integrin-mediated signaling pathway|
|cell-cell junction assembly|
|cell-cell adherens junction|
|B cell differentiation|
|lymphocyte activation involved in immune response|
|integrin binding|
|cell-cell junction organization|
|B cell activation|
|cell junction assembly|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|basolateral plasma membrane|
|cell junction organization|
|lymphocyte differentiation|
|positive regulation of protein complex assembly|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|cadherin binding|
|leukocyte differentiation|
|lymphocyte activation|
|regulation of protein complex assembly|
|cell-cell adhesion|
|positive regulation of cellular component biogenesis|
|cell junction|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|calcium ion binding|
|cell morphogenesis|
|cellular component morphogenesis|
|protein homodimerization activity|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|cell activation|
|immune effector process|
|positive regulation of cellular component organization|
|transmembrane transport|
|peptide transport|
|amide transport|
|nitrogen compound transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.81|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.14|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8462
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDH17 Expression in NALM6 Cells: 0.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>