CDH17

Entrez Summary: N/A
UniProt Summary: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. {ECO:0000269|PubMed:8153632}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

proton-dependent oligopeptide secondary active transmembrane transporter activity
positive regulation of integrin activation by cell surface receptor linked signal transduction
germinal center B cell differentiation
positive regulation of integrin activation
oligopeptide transmembrane transport
oligopeptide transport
marginal zone B cell differentiation
regulation of integrin activation
mature B cell differentiation involved in immune response
mature B cell differentiation
cell-cell adhesion mediated by cadherin
catenin complex
spleen development
transporter activity
B cell activation involved in immune response
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cytoskeletal protein binding
adherens junction organization
integrin-mediated signaling pathway
cell-cell junction assembly
cell-cell adherens junction
B cell differentiation
lymphocyte activation involved in immune response
integrin binding
cell-cell junction organization
B cell activation
cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules
basolateral plasma membrane
cell junction organization
lymphocyte differentiation
positive regulation of protein complex assembly
cell-cell adhesion via plasma-membrane adhesion molecules
cadherin binding
leukocyte differentiation
lymphocyte activation
regulation of protein complex assembly
cell-cell adhesion
positive regulation of cellular component biogenesis
cell junction