CDH18

Entrez Summary: N/A
UniProt Summary: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.93
QNZ 0.01μM R05 exp241	1.74

Cadherin C
Cadherin

cell-cell adhesion mediated by cadherin
catenin complex
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cytoskeletal protein binding
adherens junction organization
cell-cell junction assembly
cell-cell adherens junction
cell-cell junction organization
cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules
cell junction organization
cell-cell adhesion via plasma-membrane adhesion molecules
cadherin binding
cell-cell adhesion
cell surface
calcium ion binding
cell morphogenesis
cellular component morphogenesis
protein homodimerization activity
cell adhesion
biological adhesion