CDH23 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= CDH23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDH23
  * **<color #00a2e8>Official Name</color>**: cadherin related 23
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64072|64072]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H251|Q9H251]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDH23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDH23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605516|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated with breast cancer. Alternative splice variants encoding different isoforms have been described. [provided by RefSeq, May 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|equilibrioception|
|inner ear receptor cell stereocilium organization|
|stereocilium|
|photoreceptor cell maintenance|
|inner ear receptor cell development|
|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|
|inner ear receptor cell differentiation|
|neuromuscular process controlling balance|
|mechanoreceptor differentiation|
|retina homeostasis|
|neuromuscular process|
|sensory perception of sound|
|sensory perception of mechanical stimulus|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|tissue homeostasis|
|inner ear development|
|locomotory behavior|
|ear development|
|visual perception|
|sensory perception of light stimulus|
|calcium ion transport|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|divalent metal ion transport|
|divalent inorganic cation transport|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|anatomical structure homeostasis|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|cell-cell adhesion|
|sensory organ development|
|cellular metal ion homeostasis|
|behavior|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|neuron projection development|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|cellular chemical homeostasis|
|ion homeostasis|
|neuron development|
|cation transport|
|cellular homeostasis|
|cell adhesion|
|biological adhesion|
|sensory perception|
|neuron differentiation|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|ion transport|
|nervous system process|
|generation of neurons|
|neurogenesis|
|homeostatic process|
|cell development|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3493
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDH23 Expression in NALM6 Cells: -0.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>