CDH23

Entrez Summary: This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated with breast cancer. Alternative splice variants encoding different isoforms have been described. [provided by RefSeq, May 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

equilibrioception
inner ear receptor cell stereocilium organization
stereocilium
photoreceptor cell maintenance
inner ear receptor cell development
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
inner ear receptor cell differentiation
neuromuscular process controlling balance
mechanoreceptor differentiation
retina homeostasis
neuromuscular process
sensory perception of sound
sensory perception of mechanical stimulus
homophilic cell adhesion via plasma membrane adhesion molecules
tissue homeostasis
inner ear development
locomotory behavior
ear development
visual perception
sensory perception of light stimulus
calcium ion transport
cell-cell adhesion via plasma-membrane adhesion molecules
divalent metal ion transport
divalent inorganic cation transport
multicellular organismal homeostasis
regulation of cytosolic calcium ion concentration
anatomical structure homeostasis
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cell-cell adhesion
sensory organ development
cellular metal ion homeostasis
behavior
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
neuron projection development