CDH4

Entrez Summary: N/A
UniProt Summary: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cell-cell adhesion mediated by cadherin
catenin complex
positive regulation of axon extension
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
cytoskeletal protein binding
adherens junction organization
positive regulation of axonogenesis
regulation of axon extension
cell-cell adherens junction
cell-cell junction assembly
regulation of extent of cell growth
cell-cell junction organization
positive regulation of cell morphogenesis involved in differentiation
positive regulation of cell growth
cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules
positive regulation of developmental growth
regulation of cell size
regulation of axonogenesis
cell junction organization
cell-cell adhesion via plasma-membrane adhesion molecules
positive regulation of growth
axon guidance
neuron projection guidance
positive regulation of neuron projection development
regulation of cell morphogenesis involved in differentiation
cadherin binding
regulation of developmental growth
positive regulation of neuron differentiation
axonogenesis
regulation of cellular component size
positive regulation of cell projection organization
axon development
regulation of cell growth
cell morphogenesis involved in neuron differentiation
positive regulation of neurogenesis
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
regulation of cell morphogenesis