CDIP1

Entrez Summary: N/A
UniProt Summary: Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner. {ECO:0000269|PubMed:17599062}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cytoplasmic side of late endosome membrane
cytoplasmic side of lysosomal membrane
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
intrinsic apoptotic signaling pathway by p53 class mediator
intrinsic apoptotic signaling pathway in response to DNA damage
tumor necrosis factor-mediated signaling pathway
signal transduction by p53 class mediator
intrinsic apoptotic signaling pathway
cellular response to tumor necrosis factor
response to tumor necrosis factor
apoptotic signaling pathway
cytokine-mediated signaling pathway
molecular function
cellular response to DNA damage stimulus
apoptotic process
cellular response to cytokine stimulus
programmed cell death
cell death
response to cytokine
intracellular signal transduction
cellular response to stress