CDK2AP2

Entrez Summary: N/A
UniProt Summary: Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes (By similarity). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148). {ECO:0000250|UniProtKB:Q9CPY4, ECO:0000269|PubMed:23781148}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of stem cell division
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of cell cycle G1/S phase transition
regulation of G1/S transition of mitotic cell cycle
regulation of cell cycle G1/S phase transition
regulation of cell division
regulation of microtubule cytoskeleton organization
negative regulation of mitotic cell cycle phase transition
regulation of microtubule-based process
negative regulation of cell cycle phase transition
negative regulation of mitotic cell cycle
microtubule
negative regulation of cell cycle process
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
regulation of cytoskeleton organization
negative regulation of cell cycle
regulation of mitotic cell cycle
regulation of cell cycle process
regulation of cell cycle
regulation of organelle organization