CDKN3

Entrez Summary: The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein tyrosine/serine/threonine phosphatase activity
protein serine/threonine phosphatase activity
regulation of cyclin-dependent protein serine/threonine kinase activity
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
regulation of cyclin-dependent protein kinase activity
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
cell cycle arrest
protein dephosphorylation
mitotic cell cycle phase transition
cell cycle phase transition
dephosphorylation
regulation of protein serine/threonine kinase activity
negative regulation of cell cycle
mitotic cell cycle process
negative regulation of cell population proliferation
mitotic cell cycle
perinuclear region of cytoplasm
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
cell cycle process
regulation of cell cycle
cell cycle
regulation of protein phosphorylation
regulation of phosphorylation
regulation of cell population proliferation
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process