CDO1 [The Human Chemical-Genetic Interaction Map Project]

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======= CDO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDO1
  * **<color #00a2e8>Official Name</color>**: cysteine dioxygenase type 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1036|1036]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16878|Q16878]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603943|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CDO I|
|DUF1637|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cysteine dioxygenase activity|
|taurine biosynthetic process|
|alkanesulfonate biosynthetic process|
|L-cysteine metabolic process|
|cysteine catabolic process|
|L-cysteine catabolic process|
|alkanesulfonate metabolic process|
|taurine metabolic process|
|cysteine metabolic process|
|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|
|sulfur amino acid catabolic process|
|serine family amino acid catabolic process|
|sulfur amino acid biosynthetic process|
|ferrous iron binding|
|response to glucagon|
|sulfur amino acid metabolic process|
|serine family amino acid metabolic process|
|lactation|
|sulfur compound catabolic process|
|body fluid secretion|
|cellular amino acid biosynthetic process|
|response to cAMP|
|alpha-amino acid catabolic process|
|response to amino acid|
|cellular amino acid catabolic process|
|response to ethanol|
|mammary gland development|
|xenobiotic metabolic process|
|response to organophosphorus|
|response to glucocorticoid|
|response to purine-containing compound|
|response to corticosteroid|
|sulfur compound biosynthetic process|
|cellular response to xenobiotic stimulus|
|alpha-amino acid metabolic process|
|response to alcohol|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|response to xenobiotic stimulus|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|response to antibiotic|
|cellular amino acid metabolic process|
|response to steroid hormone|
|response to acid chemical|
|sulfur compound metabolic process|
|response to peptide hormone|
|gland development|
|small molecule catabolic process|
|response to peptide|
|regulation of body fluid levels|
|inflammatory response|
|response to toxic substance|
|small molecule biosynthetic process|
|response to lipid|
|carboxylic acid metabolic process|
|response to hormone|
|response to organic cyclic compound|
|oxidation-reduction process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|secretion|
|defense response|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12266
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDO1 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>