CDO1

Entrez Summary: N/A
UniProt Summary: Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CDO I
DUF1637

cysteine dioxygenase activity
taurine biosynthetic process
alkanesulfonate biosynthetic process
L-cysteine metabolic process
cysteine catabolic process
L-cysteine catabolic process
alkanesulfonate metabolic process
taurine metabolic process
cysteine metabolic process
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
sulfur amino acid catabolic process
serine family amino acid catabolic process
sulfur amino acid biosynthetic process
ferrous iron binding
response to glucagon
sulfur amino acid metabolic process
serine family amino acid metabolic process
lactation
sulfur compound catabolic process
body fluid secretion
cellular amino acid biosynthetic process
response to cAMP
alpha-amino acid catabolic process
response to amino acid
cellular amino acid catabolic process
response to ethanol
mammary gland development
xenobiotic metabolic process
response to organophosphorus
response to glucocorticoid
response to purine-containing compound
response to corticosteroid
sulfur compound biosynthetic process
cellular response to xenobiotic stimulus
alpha-amino acid metabolic process
response to alcohol
organic acid catabolic process
carboxylic acid catabolic process
response to xenobiotic stimulus
carboxylic acid biosynthetic process