CDX4
Gene Information
- Official Symbol: CDX4
- Official Name: caudal type homeobox 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 1046
- UniProt: O14627
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Caudal act |
| Homeobox |
GO Terms
| labyrinthine layer development |
| anterior/posterior axis specification |
| axis specification |
| embryonic placenta development |
| placenta development |
| anterior/posterior pattern specification |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| regionalization |
| in utero embryonic development |
| reproductive structure development |
| reproductive system development |
| embryonic organ development |
| pattern specification process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| blood vessel development |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| vasculature development |
| cardiovascular system development |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| developmental process involved in reproduction |
| DNA-binding transcription factor activity |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| embryo development |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BRD2 inhibitor II 20μM R07 exp341 | -1.76 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/694
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/26 |
| bone | 0/26 |
| breast | 0/30 |
| central nervous system | 0/49 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/11 |
| fibroblast | 0/1 |
| gastric | 0/14 |
| kidney | 0/18 |
| liver | 0/19 |
| lung | 0/72 |
| lymphocyte | 0/16 |
| ovary | 0/25 |
| pancreas | 0/22 |
| peripheral nervous system | 0/15 |
| plasma cell | 0/12 |
| prostate | 0/1 |
| skin | 0/20 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/28 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15939
- Expression level (log2 read counts): -7.68
Expression Distribution
CDX4 Expression in NALM6 Cells: -7.68
