CELSR1 [The Human Chemical-Genetic Interaction Map Project]

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======= CELSR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CELSR1
  * **<color #00a2e8>Official Name</color>**: cadherin EGF LAG seven-pass G-type receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9620|9620]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NYQ6|Q9NYQ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CELSR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CELSR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604523|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor that may have an important role in cell/cell signaling during nervous system formation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin|
|DUF3497|
|Dicty CAR|
|Laminin G 2|
|Laminin EGF|
|7tm 2|
|Laminin G 1|
|GPS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization involved in establishment of planar polarity|
|lateral sprouting involved in lung morphogenesis|
|orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis|
|planar dichotomous subdivision of terminal units involved in lung branching morphogenesis|
|dichotomous subdivision of terminal units involved in lung branching|
|establishment of body hair planar orientation|
|establishment of body hair or bristle planar orientation|
|establishment of planar polarity of embryonic epithelium|
|lateral sprouting from an epithelium|
|dichotomous subdivision of an epithelial terminal unit|
|apical protein localization|
|planar cell polarity pathway involved in neural tube closure|
|regulation of establishment of planar polarity involved in neural tube closure|
|regulation of epithelial tube formation|
|establishment of tissue polarity|
|establishment of planar polarity|
|epithelial tube branching involved in lung morphogenesis|
|morphogenesis of a polarized epithelium|
|lung morphogenesis|
|hair follicle development|
|skin epidermis development|
|hair cycle process|
|molting cycle process|
|Rho protein signal transduction|
|neural tube closure|
|tube closure|
|hair cycle|
|molting cycle|
|Wnt signaling pathway, planar cell polarity pathway|
|inner ear morphogenesis|
|primary neural tube formation|
|neural tube formation|
|regulation of establishment of planar polarity|
|ear morphogenesis|
|neuron migration|
|embryonic epithelial tube formation|
|regulation of embryonic development|
|branching morphogenesis of an epithelial tube|
|epithelial tube formation|
|non-canonical Wnt signaling pathway|
|transmembrane signaling receptor activity|
|morphogenesis of embryonic epithelium|
|tube formation|
|protein dimerization activity|
|morphogenesis of a branching epithelium|
|neural tube development|
|morphogenesis of a branching structure|
|lung development|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|respiratory tube development|
|regulation of morphogenesis of an epithelium|
|inner ear development|
|locomotory behavior|
|respiratory system development|
|anterior/posterior pattern specification|
|ear development|
|Ras protein signal transduction|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|small GTPase mediated signal transduction|
|regionalization|
|regulation of actin cytoskeleton organization|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|skin development|
|regulation of actin filament-based process|
|epidermis development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|wound healing|
|cell-cell adhesion|
|regulation of cytoskeleton organization|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|behavior|
|response to wounding|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|calcium ion binding|
|G protein-coupled receptor activity|
|tube development|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|embryo development|
|central nervous system development|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|epithelium development|
|cell-cell signaling|
|regulation of organelle organization|
|locomotion|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|intracellular signal transduction|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.89|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.76|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.76|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4554
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CELSR1 Expression in NALM6 Cells: 0.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>