CELSR1

Gene Information

Official Symbol: CELSR1
Official Name: cadherin EGF LAG seven-pass G-type receptor 1
Aliases and Previous Symbols: N/A
Entrez ID: 9620
UniProt: Q9NYQ6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor that may have an important role in cell/cell signaling during nervous system formation.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4554
Expression level (log2 read counts): 0.43

Expression Distribution

Screen	Score
UM131593 0.2μM R03 exp106	-1.89
BI-2536 0.0042μM R03 exp95	-1.76
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.76
CAY10603 0.55μM R08 exp467	1.87

Cadherin
DUF3497
Dicty CAR
Laminin G 2
Laminin EGF
7tm 2
Laminin G 1
GPS

protein localization involved in establishment of planar polarity
lateral sprouting involved in lung morphogenesis
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
dichotomous subdivision of terminal units involved in lung branching
establishment of body hair planar orientation
establishment of body hair or bristle planar orientation
establishment of planar polarity of embryonic epithelium
lateral sprouting from an epithelium
dichotomous subdivision of an epithelial terminal unit
apical protein localization
planar cell polarity pathway involved in neural tube closure
regulation of establishment of planar polarity involved in neural tube closure
regulation of epithelial tube formation
establishment of tissue polarity
establishment of planar polarity
epithelial tube branching involved in lung morphogenesis
morphogenesis of a polarized epithelium
lung morphogenesis
hair follicle development
skin epidermis development
hair cycle process
molting cycle process
Rho protein signal transduction
neural tube closure
tube closure
hair cycle
molting cycle
Wnt signaling pathway, planar cell polarity pathway
inner ear morphogenesis
primary neural tube formation
neural tube formation
regulation of establishment of planar polarity
ear morphogenesis
neuron migration
embryonic epithelial tube formation
regulation of embryonic development
branching morphogenesis of an epithelial tube
epithelial tube formation
non-canonical Wnt signaling pathway