CELSR2

Entrez Summary: The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor that may have an important role in cell/cell signaling during nervous system formation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

neural plate anterior/posterior regionalization
neural plate regionalization
neural plate pattern specification
dendrite morphogenesis
Wnt signaling pathway, planar cell polarity pathway
dendrite development
regulation of establishment of planar polarity
non-canonical Wnt signaling pathway
homophilic cell adhesion via plasma membrane adhesion molecules
regulation of morphogenesis of an epithelium
anterior/posterior pattern specification
regulation of animal organ morphogenesis
cell-cell adhesion via plasma-membrane adhesion molecules
regionalization
cell-cell signaling by wnt
Wnt signaling pathway
regulation of cell-cell adhesion
cell surface receptor signaling pathway involved in cell-cell signaling
cell morphogenesis involved in neuron differentiation
pattern specification process
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell-cell adhesion
cell part morphogenesis
cell morphogenesis involved in differentiation
neuron projection development
regulation of cell adhesion
calcium ion binding
cell morphogenesis
G protein-coupled receptor activity
neuron development
cellular component morphogenesis
cell adhesion
biological adhesion
neuron differentiation
regulation of anatomical structure morphogenesis
cell-cell signaling
plasma membrane bounded cell projection organization
cell projection organization