CENPC

Entrez Summary: N/A
UniProt Summary: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cyclosporin-A 3μM R07 exp348	-1.9
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.75
BRD2 inhibitor II 20μM R07 exp341	-1.73
LLY-283 2.6μM R06 exp290	-1.71
Atovaquone 15μM R08 exp451	1.71

Global Fraction of Cell Lines Where Essential: 42/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	3/25
breast	1/33
central nervous system	1/56
cervix	0/4
colorectal	3/17
esophagus	0/13
fibroblast	0/1
gastric	3/15
kidney	2/21
liver	0/20
lung	8/75
lymphocyte	1/14
ovary	1/26
pancreas	1/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	0/1
skin	2/24
soft tissue	1/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	1/5

Expression Distribution

Cupin 2
Mif2

attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation
attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation
centromeric DNA binding
nuclear pericentric heterochromatin
condensed nuclear chromosome kinetochore
attachment of mitotic spindle microtubules to kinetochore
condensed nuclear chromosome, centromeric region
kinetochore assembly
pericentric heterochromatin
kinetochore organization
attachment of spindle microtubules to kinetochore
Flemming body
CENP-A containing chromatin organization
CENP-A containing nucleosome assembly
chromatin remodeling at centromere
centromere complex assembly
DNA replication-independent nucleosome assembly
DNA replication-independent nucleosome organization
mitotic metaphase plate congression
histone exchange
metaphase plate congression
cleavage furrow
homologous chromosome segregation
intercellular bridge
establishment of chromosome localization
chromosome localization
ATP-dependent chromatin remodeling
kinetochore
meiotic chromosome segregation
mitotic sister chromatid segregation
meiosis I
meiosis I cell cycle process
nucleosome assembly
chromatin assembly
sister chromatid segregation
mitotic nuclear division
meiotic nuclear division
chromatin assembly or disassembly
nucleosome organization
midbody