CH25H

Entrez Summary: N/A
UniProt Summary: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation. {ECO:0000250|UniProtKB:Q9Z0F5, ECO:0000269|PubMed:9852097}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cholesterol 25-hydroxylase activity
C-4 methylsterol oxidase activity
B cell chemotaxis
bile acid biosynthetic process
steroid hydroxylase activity
bile acid metabolic process
lymphocyte chemotaxis
sterol biosynthetic process
lymphocyte migration
cholesterol metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
iron ion binding
sterol metabolic process
leukocyte chemotaxis
monocarboxylic acid biosynthetic process
organic hydroxy compound biosynthetic process
cell chemotaxis
steroid metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
alcohol metabolic process
leukocyte migration
organic hydroxy compound metabolic process
monocarboxylic acid metabolic process
chemotaxis
taxis
lipid biosynthetic process
small molecule biosynthetic process
carboxylic acid metabolic process
endoplasmic reticulum membrane
cell migration
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
localization of cell
cell motility
lipid metabolic process
organic cyclic compound biosynthetic process
locomotion