CHAC2

Entrez Summary: N/A
UniProt Summary: Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. {ECO:0000269|PubMed:27913623}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glutathione specific gamma-glutamylcyclotransferase activity
gamma-glutamylcyclotransferase activity
glutathione catabolic process
glutathione biosynthetic process
nonribosomal peptide biosynthetic process
cellular modified amino acid catabolic process
peptide catabolic process
cellular modified amino acid biosynthetic process
glutathione metabolic process
sulfur compound catabolic process
cofactor catabolic process
sulfur compound biosynthetic process
cellular modified amino acid metabolic process
cofactor biosynthetic process
sulfur compound metabolic process
peptide biosynthetic process
cofactor metabolic process
cellular component
amide biosynthetic process
peptide metabolic process
molecular function
cellular amide metabolic process
organonitrogen compound catabolic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
organic substance catabolic process
cellular catabolic process