CHD3 [The Human Chemical-Genetic Interaction Map Project]

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======= CHD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHD3
  * **<color #00a2e8>Official Name</color>**: chromodomain helicase DNA binding protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1107|1107]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12873|Q12873]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602120|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:9804427}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHD|
|DUF1086|
|DUF1087|
|Chromo|
|CHDNT|
|SNF2 N|
|Helicase C|
|HDA2-3|
|CHDCT2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|double-stranded DNA helicase activity|
|nucleosome-dependent ATPase activity|
|NuRD complex|
|helicase activity|
|DNA helicase activity|
|ATP-dependent chromatin remodeling|
|centrosome cycle|
|microtubule organizing center organization|
|DNA duplex unwinding|
|DNA geometric change|
|spindle organization|
|chromatin assembly or disassembly|
|microtubule organizing center|
|chromatin remodeling|
|regulation of signal transduction by p53 class mediator|
|ATPase activity|
|DNA conformation change|
|microtubule cytoskeleton organization|
|centrosome|
|microtubule-based process|
|chromatin organization|
|zinc ion binding|
|nucleolus|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|cell cycle|
|RNA binding|
|DNA binding|
|ATP binding|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.9|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.86|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.86|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.77|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.74|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14968
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHD3 Expression in NALM6 Cells: 8.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>