CHD3

Entrez Summary: N/A
UniProt Summary: Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:9804427}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BS-181 20μM R08 exp461	-1.9
Erlotinib 10μM R05 exp216	-1.86
TNF-alpha 44ng/ml R08 exp533	-1.86
ETC-159 50μM R08 exp480	-1.77
Hypoxia 5%O2 R04 exp191	-1.74
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	1.7

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

double-stranded DNA helicase activity
nucleosome-dependent ATPase activity
NuRD complex
helicase activity
DNA helicase activity
ATP-dependent chromatin remodeling
centrosome cycle
microtubule organizing center organization
DNA duplex unwinding
DNA geometric change
spindle organization
chromatin assembly or disassembly
microtubule organizing center
chromatin remodeling
regulation of signal transduction by p53 class mediator
ATPase activity
DNA conformation change
microtubule cytoskeleton organization
centrosome
microtubule-based process
chromatin organization
zinc ion binding
nucleolus
cell cycle process
chromosome organization
cytoskeleton organization
cell cycle
RNA binding
DNA binding
ATP binding
regulation of intracellular signal transduction