CHI3L1

Gene Information

Official Symbol: CHI3L1
Official Name: chitinase 3 like 1
Aliases and Previous Symbols: N/A
Entrez ID: 1116
UniProt: P36222
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009].
UniProt Summary: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:19414556, ECO:0000269|PubMed:20558631, ECO:0000269|PubMed:9492324}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8163
Expression level (log2 read counts): -0.26

Expression Distribution

Screen	Score
Sucrose 20000μM R06 exp298	-1.8
Oligomycin-A 2μM R00 exp25	1.77

interleukin-8 secretion
chitinase activity
chitin binding
interleukin-8 production
activation of NF-kappaB-inducing kinase activity
positive regulation of peptidyl-threonine phosphorylation
response to interleukin-6
regulation of peptidyl-threonine phosphorylation
cytokine secretion
specific granule lumen
positive regulation of NIK/NF-kappaB signaling
NIK/NF-kappaB signaling
regulation of NIK/NF-kappaB signaling
extracellular matrix structural constituent
cytokine production
protein secretion
establishment of protein localization to extracellular region
positive regulation of angiogenesis
protein localization to extracellular region
positive regulation of protein kinase B signaling
lung development
cartilage development
respiratory tube development
carbohydrate binding
peptide secretion
cellular response to interleukin-1
positive regulation of vasculature development
respiratory system development
response to interleukin-1
positive regulation of ERK1 and ERK2 cascade
response to mechanical stimulus
regulation of protein kinase B signaling
connective tissue development
extracellular matrix
cellular response to tumor necrosis factor
response to tumor necrosis factor
regulation of angiogenesis
regulation of ERK1 and ERK2 cascade
regulation of vasculature development
activation of protein kinase activity