CHRM2 [The Human Chemical-Genetic Interaction Map Project]

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======= CHRM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHRM2
  * **<color #00a2e8>Official Name</color>**: cholinergic receptor muscarinic 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1129|1129]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08172|P08172]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHRM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHRM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118493|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|asymmetric synapse|
|phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway|
|symmetric synapse|
|G protein-coupled acetylcholine receptor activity|
|adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway|
|arrestin family protein binding|
|cholinergic synapse|
|G protein-coupled acetylcholine receptor signaling pathway|
|acetylcholine receptor signaling pathway|
|response to acetylcholine|
|cellular response to acetylcholine|
|G protein-coupled serotonin receptor activity|
|G protein-coupled serotonin receptor signaling pathway|
|neurotransmitter receptor activity|
|postsynaptic signal transduction|
|serotonin receptor signaling pathway|
|integral component of postsynaptic membrane|
|axon terminus|
|clathrin-coated vesicle membrane|
|integral component of presynaptic membrane|
|regulation of smooth muscle contraction|
|regulation of synaptic vesicle exocytosis|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|cellular response to dopamine|
|response to dopamine|
|signal transduction involved in cellular response to ammonium ion|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|regulation of neurotransmitter secretion|
|response to catecholamine|
|response to monoamine|
|regulation of synaptic vesicle cycle|
|cellular response to ammonium ion|
|regulation of neurotransmitter transport|
|regulation of muscle contraction|
|regulation of regulated secretory pathway|
|response to ammonium ion|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of exocytosis|
|regulation of muscle system process|
|regulation of heart contraction|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|response to virus|
|regulation of blood circulation|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|neuronal cell body|
|cellular response to drug|
|dendrite|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|cellular response to organic cyclic compound|
|cell junction|
|regulation of vesicle-mediated transport|
|regulation of system process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|G protein-coupled receptor activity|
|regulation of secretion by cell|
|regulation of secretion|
|membrane organization|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell-cell signaling|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.1|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-1.84|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.82|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.82|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.73|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7428
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHRM2 Expression in NALM6 Cells: -1.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>