CHRM2

Gene Information

Official Symbol: CHRM2
Official Name: cholinergic receptor muscarinic 2
Aliases and Previous Symbols: N/A
Entrez ID: 1129
UniProt: P08172
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R08 exp434	-2.1
CyclicAMP 200μM R08 exp475	-1.84
HMS-I2 1μM R06 exp286	-1.82
YM155 0.0002μM R01 exp61	-1.82
CAY10603 0.55μM R08 exp467	1.73
Actinomycin-D 0.01μM R00 exp4	1.74

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7428
Expression level (log2 read counts): -1.4

Expression Distribution

asymmetric synapse
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
symmetric synapse
G protein-coupled acetylcholine receptor activity
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
arrestin family protein binding
cholinergic synapse
G protein-coupled acetylcholine receptor signaling pathway
acetylcholine receptor signaling pathway
response to acetylcholine
cellular response to acetylcholine
G protein-coupled serotonin receptor activity
G protein-coupled serotonin receptor signaling pathway
neurotransmitter receptor activity
postsynaptic signal transduction
serotonin receptor signaling pathway
integral component of postsynaptic membrane
axon terminus
clathrin-coated vesicle membrane
integral component of presynaptic membrane
regulation of smooth muscle contraction
regulation of synaptic vesicle exocytosis
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
cellular response to dopamine
response to dopamine
signal transduction involved in cellular response to ammonium ion
phospholipase C-activating G protein-coupled receptor signaling pathway
cellular response to monoamine stimulus
cellular response to catecholamine stimulus
regulation of neurotransmitter secretion
response to catecholamine
response to monoamine
regulation of synaptic vesicle cycle
cellular response to ammonium ion
regulation of neurotransmitter transport
regulation of muscle contraction
regulation of regulated secretory pathway
response to ammonium ion
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
regulation of exocytosis