CHRM3

Gene Information

Official Symbol: CHRM3
Official Name: cholinergic receptor muscarinic 3
Aliases and Previous Symbols: N/A
Entrez ID: 1131
UniProt: P20309
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016].
UniProt Summary: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. {ECO:0000269|PubMed:7565628}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9563
Expression level (log2 read counts): -0.54

Expression Distribution

7TM GPCR Srsx
7tm 1

positive regulation of vascular smooth muscle contraction
saliva secretion
G protein-coupled acetylcholine receptor activity
regulation of vascular smooth muscle contraction
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
acetylcholine binding
G protein-coupled acetylcholine receptor signaling pathway
secretion by tissue
synaptic transmission, cholinergic
phosphatidylinositol phospholipase C activity
acetylcholine receptor signaling pathway
positive regulation of smooth muscle contraction
positive regulation of vasoconstriction
response to acetylcholine
cellular response to acetylcholine
G protein-coupled serotonin receptor signaling pathway
G protein-coupled serotonin receptor activity
neurotransmitter receptor activity
serotonin receptor signaling pathway
postsynaptic signal transduction
positive regulation of muscle contraction
integral component of postsynaptic density membrane
smooth muscle contraction
axon terminus
regulation of vasoconstriction
integral component of presynaptic membrane
regulation of smooth muscle contraction
positive regulation of blood circulation
body fluid secretion
digestive system process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
cellular response to dopamine
response to dopamine
signal transduction involved in cellular response to ammonium ion
cellular response to catecholamine stimulus
cellular response to monoamine stimulus
response to catecholamine
response to monoamine
digestion
cellular response to ammonium ion