CHRNA10

Entrez Summary: N/A
UniProt Summary: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. {ECO:0000269|PubMed:11752216}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Neur chan memb
Neur chan LBD

cholinergic synapse
detection of mechanical stimulus involved in sensory perception of sound
acetylcholine-gated cation-selective channel activity
integral component of postsynaptic specialization membrane
synaptic transmission, cholinergic
detection of mechanical stimulus involved in sensory perception
detection of mechanical stimulus
extracellular ligand-gated ion channel activity
calcium channel activity
excitatory postsynaptic potential
negative regulation of ERK1 and ERK2 cascade
chemical synaptic transmission, postsynaptic
inner ear morphogenesis
regulation of postsynaptic membrane potential
ear morphogenesis
detection of external stimulus
detection of abiotic stimulus
perikaryon
transmembrane signaling receptor activity
sensory perception of sound
negative regulation of MAPK cascade
sensory perception of mechanical stimulus
inner ear development
calcium ion transmembrane transport
response to mechanical stimulus
ear development
calcium ion transport
sensory organ morphogenesis
synapse
positive regulation of cytosolic calcium ion concentration
embryonic organ morphogenesis
regulation of ERK1 and ERK2 cascade
divalent metal ion transport
axon
divalent inorganic cation transport
neuron projection
regulation of cytosolic calcium ion concentration
signaling receptor binding
negative regulation of protein phosphorylation
anterograde trans-synaptic signaling