CHRNA5

Entrez Summary: The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010].
UniProt Summary: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Neur chan memb
Neur chan LBD

behavioral response to nicotine
ligand-gated ion channel activity
dopaminergic synapse
acetylcholine receptor activity
acetylcholine-gated cation-selective channel activity
acetylcholine-gated channel complex
acetylcholine binding
synaptic transmission, cholinergic
neuromuscular synaptic transmission
extracellular ligand-gated ion channel activity
response to nicotine
excitatory postsynaptic potential
chemical synaptic transmission, postsynaptic
regulation of synaptic vesicle exocytosis
regulation of postsynaptic membrane potential
regulation of neurotransmitter secretion
regulation of synaptic vesicle cycle
regulation of neurotransmitter transport
adult behavior
regulation of regulated secretory pathway
postsynaptic membrane
regulation of exocytosis
synapse
neuron projection
regulation of neurotransmitter levels
anterograde trans-synaptic signaling
chemical synaptic transmission
cell surface receptor signaling pathway involved in cell-cell signaling
regulation of membrane potential
trans-synaptic signaling
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
synaptic signaling
response to toxic substance
cell junction
regulation of vesicle-mediated transport
behavior
regulation of secretion by cell
regulation of secretion
regulation of cellular localization