CHRNA6

Entrez Summary: N/A
UniProt Summary: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Neur chan LBD
Neur chan memb

dopaminergic synapse
acetylcholine receptor activity
acetylcholine-gated cation-selective channel activity
acetylcholine binding
acetylcholine-gated channel complex
synaptic transmission, cholinergic
neuromuscular synaptic transmission
regulation of dopamine secretion
integral component of postsynaptic membrane
extracellular ligand-gated ion channel activity
response to nicotine
membrane depolarization
integral component of presynaptic membrane
regulation of catecholamine secretion
excitatory postsynaptic potential
chemical synaptic transmission, postsynaptic
regulation of synaptic vesicle exocytosis
regulation of amine transport
regulation of response to drug
regulation of postsynaptic membrane potential
regulation of neurotransmitter secretion
regulation of synaptic vesicle cycle
regulation of neurotransmitter transport
regulation of regulated secretory pathway
regulation of exocytosis
synapse
neuron projection
regulation of neurotransmitter levels
anterograde trans-synaptic signaling
chemical synaptic transmission
cell surface receptor signaling pathway involved in cell-cell signaling
regulation of membrane potential
trans-synaptic signaling
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
synaptic signaling
response to toxic substance
cell junction
regulation of vesicle-mediated transport
regulation of ion transport