CHSY1

Entrez Summary: This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. These enzymes possess dual glucuronyltransferase and galactosaminyltransferase activity and play critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan involved in many biological processes including cell proliferation and morphogenesis. Decreased expression of this gene may play a role in colorectal cancer, and mutations in this gene are a cause of temtamy preaxial brachydactyly syndrome. [provided by RefSeq, Dec 2011].
UniProt Summary: Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling. {ECO:0000269|PubMed:11514575, ECO:0000269|PubMed:21129727}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CHGN
Fringe

N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
sulfation
chondroitin sulfate biosynthetic process
chondroitin sulfate proteoglycan biosynthetic process
proximal/distal pattern formation
positive regulation of smoothened signaling pathway
chondroitin sulfate metabolic process
chondrocyte development
chondroitin sulfate proteoglycan metabolic process
proteoglycan biosynthetic process
negative regulation of ossification
regulation of smoothened signaling pathway
chondrocyte differentiation
proteoglycan metabolic process
Golgi cisterna membrane
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
bone morphogenesis
glycosaminoglycan metabolic process
aminoglycan metabolic process
cartilage development
sulfur compound biosynthetic process
regulation of ossification
bone development
connective tissue development
skeletal system morphogenesis
glycoprotein biosynthetic process
regionalization
sulfur compound metabolic process
glycoprotein metabolic process
pattern specification process
skeletal system development
response to nutrient levels
response to extracellular stimulus
carbohydrate derivative biosynthetic process
Golgi membrane
animal organ morphogenesis
oxoacid metabolic process