CISH

Entrez Summary: The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
UniProt Summary: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SH2
SOCS box

1-phosphatidylinositol-3-kinase regulator activity
interleukin-7-mediated signaling pathway
phosphatidylinositol 3-kinase complex
protein kinase C-activating G protein-coupled receptor signaling pathway
cellular response to interleukin-7
response to interleukin-7
negative regulation of insulin receptor signaling pathway
negative regulation of cellular response to insulin stimulus
phosphatidylinositol phosphorylation
regulation of phosphatidylinositol 3-kinase activity
regulation of lipid kinase activity
regulation of insulin receptor signaling pathway
lipid phosphorylation
regulation of cellular response to insulin stimulus
regulation of phospholipid metabolic process
phosphatidylinositol metabolic process
lipid modification
glycerophospholipid metabolic process
post-translational protein modification
phospholipid metabolic process
glycerolipid metabolic process
regulation of lipid metabolic process
regulation of cell growth
cellular component
regulation of growth
cytokine-mediated signaling pathway
protein ubiquitination
molecular function
protein modification by small protein conjugation
regulation of kinase activity
organophosphate metabolic process
cellular lipid metabolic process
regulation of transferase activity
protein modification by small protein conjugation or removal
cellular response to cytokine stimulus
response to cytokine
lipid metabolic process
negative regulation of signal transduction
phosphorylation
G protein-coupled receptor signaling pathway