CKS1B

Gene Information

Official Symbol: CKS1B
Official Name: CDC28 protein kinase regulatory subunit 1B
Aliases and Previous Symbols: N/A
Entrez ID: 1163
UniProt: P61024
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2991
Expression level (log2 read counts): 6.23

Expression Distribution

cyclin-dependent protein serine/threonine kinase activator activity
cyclin-dependent protein kinase holoenzyme complex
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of cyclin-dependent protein kinase activity
SCF ubiquitin ligase complex
ubiquitin binding
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
histone binding
positive regulation of protein serine/threonine kinase activity
positive regulation of cell cycle
protein kinase binding
cell division
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of kinase activity
regulation of mitotic cell cycle
positive regulation of transferase activity
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
regulation of cell cycle
positive regulation of protein modification process
cell cycle
positive regulation of catalytic activity
regulation of protein phosphorylation
regulation of phosphorylation
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process