CLC

Entrez Summary: Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008].
UniProt Summary: Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). {ECO:0000269|PubMed:17502455}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
NFN1 0.1μM R01 exp49	-1.99
UM0129480 7μM R02 exp85	-1.74

regulation of T cell anergy
regulation of lymphocyte anergy
regulation of T cell tolerance induction
T cell apoptotic process
cysteine-type endopeptidase activity involved in apoptotic process
regulation of tolerance induction
lymphocyte apoptotic process
lysophospholipase activity
leukocyte apoptotic process
regulation of T cell cytokine production
regulation of activated T cell proliferation
regulation of T cell mediated immunity
regulation of cytokine production involved in immune response
regulation of production of molecular mediator of immune response
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
regulation of lymphocyte mediated immunity
regulation of T cell proliferation
regulation of adaptive immune response
carbohydrate binding
regulation of leukocyte mediated immunity
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
regulation of leukocyte proliferation
regulation of T cell activation
collagen-containing extracellular matrix
regulation of immune effector process
regulation of lymphocyte activation
regulation of leukocyte activation
regulation of cell activation
regulation of cytokine production
apoptotic process
programmed cell death
identical protein binding
cell death
regulation of immune response
regulation of cell population proliferation
regulation of immune system process